Informatics Publishing Limited

P. G. Yeole , S. J. Wadher , N. J. Gaikwad

Abstract

The antioxidant activities of water extract of heartwood of Pterocarpus marsupium were evaluated in different systems viz., radical scavenging activity by DPPH reduction, nitric oxide (NO) radical scavenging in sodium nitroprusside/Griess reagent system. The results indicate that the reducing power of a substance may be an indicator of its potential antioxidant activity, but it is not necessarily a linear correlation between these two activities. The extract was found to have different level of antioxidant properties in the models tested. In scavenging DPPH and nitric oxide (NO), its activity was intense (EC₅₀ = 182.74 and 66.028 μg/ml respectively). The free radical scavenging property may be one of the mechanism by which this drug is effective in several free radical mediated disease conditions.

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Vilas A. Arsul ¹, R. O. Ganjiwale ¹, P. G. Yeole ¹

Affiliations
1 P.G. Department of Quality Assurance, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442001, Maharashtra, IN

Abstract

A simple, precise, accurate, rapid and reproductive HPTLC procedure was developed for development and validation of phyllanthin in tablet dosage form at a single wavelength. The mobile phase used was a combination of Toluene-Ethyl acetate [9:1 V/V]. The detection of the combined dosage form was carried out at 200nm. The Rf value of standard phyllanthin was 0.83 ± 0.04 and matches to the phyllanthin present in polyherbal tablet. The phyllanthin content of tablet was determined and it was found to be 0.178 % w/w ±0.0016.The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.

Keywords

Polyherbal Tablets, Phyllanthin, HPTLC, Recovery.

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G. D. Dahikar ¹, P. G. Yeole ¹, R. O. Ganjiwale ¹, V. T. Rahangdale ¹

Affiliations
1 Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442001, IN

Abstract

Epilepsy is a very common disorder, characterized by seizures, which take various forms and result from episodic neuronal discharges, the form of the seizure depending on the part of the brain affected. Epilepsy affects 0.5-1% of the population. Often there is no recognizable cause, although it may develop after brain damage, such as trauma, infection or tumor growth, or other kinds of neurological disease, including various inherited neurological syndromes. Epilepsy is treated mainly with drugs, though brain surgery may be used for severe cases. Current antiepileptic drugs are effective in controlling seizures in about 70% of patients, but their use is often. It is tendency to experience anticonvulsant agent which blocks experimentally produced seizures in laboratory animal. 6-iodo-2-ethyl-4(3H)-3 (5-substituted benzothiazole-2’-yl) quinazolinones compound were prepared by condensing 5-substituted-2-amino benzothiazoles and 6-iodo-2-ethyl-3, 1-benzoxazine-4-one, then prepared compounds were evaluated for anticonvulsant activity by maximal electroshock method against standard drug like phenobarbitone at 20 mg/ kg dose. The chemical structures of all these compounds were confirmed by Mass, IR, ¹HNMR spectral and elemental analysis. Simultaneously effect of electron donating and withdrawing groups also checked on 6-iodo-2-ethyl-4(3H)-3(5- substituted benzothiazole-2’-yl) quinazolinones.

Keywords

Benzothiazole, Quinazolinone and Anticonvulsant.

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